Specific autoantibodies in patients with longstanding CRPS

Andreas Goebel

We recently published a study on antibodies found in the blood of patients with longstanding Complex Regional Pain Syndrome [1]. Antibodies are substances produced by the body’s immune system. Their best-known role is to fight infection. However sometimes they go wrong, and bind to the body’s own cells, causing dysfunction or damage. These … [Read more...]

Painful view on motor actions

Jaakko Hotta

Imagine you sprained your wrist. It’s aching, swollen and reddish. You want to move the hand to see if it is ok, but the fear of pain makes you hesitate and it takes extra effort to do it. Even thinking about movement can be unpleasant and you focus on doing things with the healthy hand. After days and weeks, as the trauma heals, the pain passes … [Read more...]

Sympathetic blocks for complex regional pain syndrome

Based largely on his clinical experience, the founding father of modern pain medicine, John J. Bonica, recommended that complex regional pain syndrome (CRPS) be treated with a series of sympathetic blocks as soon as possible after symptoms develop. Although this sometimes seems to work well, the value of this approach has been questioned because of … [Read more...]

Capturing and sharing the voice and experiences of those who are living with Complex Regional Pain Syndrome

Karen Rodham

Complex Regional Pain Syndrome (CRPS) is difficult to diagnose and is characterised by burning pain in one or more limbs, with 15-20% of patients developing long term disability [1]. The cause is unknown and there is currently no cure. As a consequence, people living with CRPS often turn to the Internet to seek CRPS-related information and support … [Read more...]

Sensory conflicts may increase limb pain in CRPS by activating mechanisms of general facilitation of nociception

Lone Knudsen

I continue to be fascinated by the perplexing symptoms of complex regional pain syndrome (CRPS). CRPS is characterised by the changeable nature of symptoms throughout the day and during the course of the disease, and patients with CRPS often perceive the affected limb as larger than its actual size (Moseley, 2005; Peltz et al., 2011). Patients with … [Read more...]

Capillary dysfunction in CRPS?

Leif ostergaard

Reports suggest that muscles lack oxygen and skin oxygenation is impaired in Complex Regional Pain Syndrome (CRPS). While CRPS might be related to tissue ischemia-reperfusion, the affected limb is often hyperperfused, suggesting that oxygen extraction is severely impaired instead. In a recent paper in Pain, we speculate that capillary flow … [Read more...]

World Congress on Pain comes to you. 1: Disentangling CRPS

Adios Buenos Aires, IASP World Congress is always such a big beast. Vast conference halls, so many possible sessions to attend, so many posters to view and in this case so many fantastic Argentinian steaks to eat and wash down with equally fantastic Malbec. But you often leave trying to make sense of what you have heard and what, if anything, … [Read more...]

New light on bone formation in CRPS?

Roberto_Perez

The variability of signs and symptoms of Complex Regional Pain Syndrome (CRPS), may represent between-patient variability in the pathological mechanisms at work. One often forgotten CRPS feature is impaired bone formation yet this has been found in up to fifty percent of patients regardless of disease duration [1]. German Surgeon Paul Sudeck … [Read more...]

A tool for communicating body perception disturbances

Ailie Turton

Some people with persistent pain have altered perceptions of parts of their body. For example they can perceive their affected limbs as having some distortions of size, perhaps with enlarged hands or very thin forearms. They can also feel that the limb is in a different position to its actual location and that areas of body or limb segments are … [Read more...]

Do People Recover from CRPS?

Debbie Bean

Complex Regional Pain Syndrome (CRPS) is a condition which can invoke fear and dread both in patients and healthcare providers.  Many patients I’ve met who have been told they’ve got CRPS have done a little searching on Dr Google and come away terrified, thinking CRPS is a life sentence, worrying it might never get any better, having read that … [Read more...]