In a recent paper by Vaso et al. (2014) it was suggested that phantom limb pain is driven primarily by activity generated within the ectopic dorsal root ganglia (DRG) (they wrote for BiM on it here). Ectopic activity is abnormal spontaneous activity generated in neuromas in the residual limb as well as in dorsal root ganglions. The authors reported … [Read more...]
It is more or less well-accepted nowadays that back pain, particularly when chronic, is best understood within a biopsychosocial framework. The implication is that treatment is more likely to be successful if it includes components that target not only physical issues but also psychological and/or social factors. This is the premise that underpins … [Read more...]
Despite our best scientific endeavors, what actually causes the pain in chronic low back pain (CLBP) often remains unclear. Approximately 85 % of chronic back pain patients are classified as having non-specific low back pain  because a definitive diagnosis cannot be given. That is, pain cannot be confidently attributed to known pathoanatomical, … [Read more...]
The Ride4Pain, PainAdelaide, Australian Pain Society, Placebo Dinner, PhysioPain Network, Explain Pain3…..that empty feeling.
People round here are getting spoilt with the smorgasbord of exciting pain-related events that are going on at the moment. We kicked it off last November with the Ride for Pain – a few hundred people riding for 2, 4, or 6 hours, taking on their personal pain challenge. The tough nuts covered 100km and climbed 2600m, before rolling to the village … [Read more...]
In a recent clinical study we showed for the first time that a large fraction (about one third) of pain relief produced by morphine (the gold standard among pain killers) is mediated by opioid receptors outside the brain. In patients undergoing knee replacement surgery, the blockade of such peripheral opioid receptors by methylnaltrexone (an opioid … [Read more...]
The Journal of Pain recently published a paper that caught our eye for its simple design and clever investigation of the role of psychosocial factors in the development of multisite pain. And if you got stuck on the word development, then you’ll know why we got excited. Previous research into this has been correlational: depression, fear of pain … [Read more...]
It is now well established that men and women show general differences in how they report and experience pain - women tend to report more pain, with greater severity and frequency than men. Examples are numerous, and range from laboratory-based pain induction studies on healthy adults through to epidemiological and clinical investigations of … [Read more...]
It is common for adolescents and children to experience chronic pain (Perquin et al., 2000). There are many negative implications associated with chronic pain such as limited social contact, lost days from school, and higher levels of anxiety and depression (Hunfeld et al., 2002; Logan, Simons, Stein, & Chastain, 2008; Walker, Guite, Duke, … [Read more...]
What to call the amplification of nociceptive signals in the CNS that contribute to widespread pain?
Clifford Woolf, who some may know as the ‘father of central sensitisation’, recently wrote a commentary to PAIN. It piqued our interest because it was about the use of the term ‘central sensitisation’, and we suspect we know people who’d insist that the term ‘central sensitisation’ should only be used to describe changes at the dorsal horn, and … [Read more...]
One good thing about music, when it hits you, you feel no pain -Bob Marley Playing music for pain relief isn’t exactly a new idea. Music has been used as a tool to promote physical and mental recovery for centuries, with the ancient Greeks initially describing music as a rational treatment strategy. Music is a highly desirable treatment tool for … [Read more...]